The Role of VDR Gene Polymorphisms in Vitamin D Supplementation

Virtual data rooms (VDRs) are secure repositories for documents used in business transactions, legal proceedings, or IPOs. The VDR is accessible through an encrypted Internet connection that permits only authorized persons to access and edit the data. Virtual data rooms are frequently used by companies involved with M&A deals, as they provide a safe and secure way for parties to exchange sensitive documents that might be compromised or leaked through email, fax or even regular mail.

The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signalling plays a role in a variety of biological effects that include the metabolic processes of calcium and phosphorous parathormone release, cell proliferation and control of adaptive and innate immunity.

A T > C base shift in the promoter region of VDR variant rs11568820 obliterates the binding site for the transcription factor Cdx2 that is upstream of exon 1e. This leads to the production of a smaller protein that has decreased transcriptional activity. The F allele is present in high frequency among Asians and Europeans, and in lower frequency in Sub-Saharan Africans.

The findings of this study enhance our understanding of the role VDR gene polymorphisms could influence the response to diet supplementation with calcitriol. People who carry the oldetowntimes.net/ TaqI polymorphism and FF genotype of the FokI polymorphism have greater transcriptional activation of VDR and are associated with increased calcium absorption and bone mineral density and reduced risk of fractures [34 35, 34[34, 35]. Further research using an overall design is needed to improve our understanding of how these genetic variants influence vitamin D supplementation as well as its clinical significance.